The article

Implant bone interface: reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo

represents the research concept of the joint project NTC and UKR:
Advanced porous biomaterials functionalized with stem cells for enhanced implant osseointegration.
This review starts with an introduction to the basics of cell-material interactions as well as common surface modification techniques. Afterwards, recent research on the impact of osteogenic processes in vitro and vivo provoked by various surface modifications is reviewed and discussed, in order to give an update on currently applied and developing implant modification techniques for enhancing osteointegration.
A key factor for a successful stable long-term integration is the initial cellular response to the implant material. Hence, cell-material interactions, which are dependent on the surface parameters, need to be considered in the implant design.
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